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Weight loss plan change mixed with medicine might minimize seizures by half: AIIMS research

NEW DELHI: Following a modified Atkins weight-reduction plan excessive in fats and low in carbohydrates and taking medicine might cut back seizures by over half in individuals with tough-to-treat epilepsy, in keeping with a research by researchers on the All India Institute of Medical Sciences.
The modified Atkins weight-reduction plan is a mix of the Atkins weight-reduction plan and a ketogenic weight-reduction plan that features meals objects comparable to soy merchandise, heavy cream, butter and oils, leafy inexperienced greens, and animal protein together with eggs, rooster, fish, and bacon.
Whereas the ketogenic weight-reduction plan has been proven to be efficient in decreasing seizures, its stringent necessities and restrictions could make it tough to observe, the researchers mentioned.
“For individuals with drug-resistant epilepsy, or those that have been unable to seek out efficient therapy to scale back seizures, it is encouraging to see that there are life-style adjustments that may be mixed with commonplace drug remedy to scale back the variety of seizures,” mentioned Manjari Tripathi, from AIIMS New Delhi.
“Our research discovered that this mixture might cut back the possibility of seizures by greater than half,” mentioned Tripathi, writer of the research revealed within the journal Neurology.
The research concerned 160 adults and adolescents who had epilepsy for greater than 10 years on common and had a minimum of 27 seizures per thirty days regardless of making an attempt a median of 4 antiseizure drugs on the most tolerated dose.
They have been randomly assigned to obtain both commonplace drug remedy alone or medicine plus the modified Atkins weight-reduction plan over six months. Contributors logged their seizures and meals.
They got meals lists, pattern menus and recipes. Carbohydrate consumption was restricted to twenty grams per day. US Federal dietary pointers advocate between 225 and 325 grams of carbs per day.
After six months, researchers discovered that 26 per cent of people that had each drug remedy and adopted the modified Atkins weight-reduction plan had greater than a 50 per cent discount in seizures in comparison with solely three per cent of the individuals who had drug remedy alone.
4 individuals within the weight-reduction plan group have been freed from seizures by the tip of the research, whereas nobody within the medication-only group was seizure-free, the researchers discovered.
The research additionally checked out high quality of life, behaviour and negative effects at six months.
The group that had drug remedy and adopted the modified Atkins weight-reduction plan confirmed an enchancment in all areas in comparison with the group that had drug remedy alone, the researchers mentioned.
They famous that 33 per cent of the individuals didn’t full the research as a consequence of poor tolerance of the weight-reduction plan, lack of profit or the shortcoming to follow-up partially as a consequence of Covid-19.
Nonetheless, the researchers mentioned tolerance of the modified Atkins weight-reduction plan was higher than what’s seen with the ketogenic weight-reduction plan.
“Whereas the modified Atkins weight-reduction plan could also be an efficient therapy in controlling seizures, additional analysis is required to establish genetic biomarkers and different elements related to the response to this weight-reduction plan,” Tripathi added.
“This may increasingly enhance affected person care by encouraging focused precision based mostly earlier use of this weight-reduction plan,” she added.
The researchers acknowledged a limitation within the research that seizures have been self-reported or reported by caregivers, so a few of them might not have been reported in any respect.

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